Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
نویسندگان
چکیده
منابع مشابه
Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
Mutations in GFI1B are associated with inherited bleeding disorders called GFI1B-related thrombocytopenias. We show here that mice with a megakaryocyte-specific Gfi1b deletion exhibit a macrothrombocytopenic phenotype along a megakaryocytic dysplasia reminiscent of GFI1B-related thrombocytopenia. GFI1B deficiency increases megakaryocyte proliferation and affects their ploidy, but also abrogates...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2017
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2016.150375